ASSOCIATION ANALYSIS OF MFG-E8 WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN CHINESE HAN POPULATION

来源 :The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会) | 被引量 : 0次 | 上传用户:li_uwx
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  Objective: Recently, apoptosis clearance has been proposed to involve in the pathophysiology of chronic obstructive pulmonary disease (COPD).It has been suggested that Milk fat globule-EGF factor 8 (MFG-E8) promoted the engulfment of apoptotic cells, therefore, we investigated whether plasma concentration and gene polymorphisms of MFG-E8 were associated with COPD in this study.Methods:MFG-E8 rs4945 C>A and rs1878326 C>A gene polymorphisms were genotyped in cases of 236 COPD Chinese patients and 247 healthy individuals respectively with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
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