Mitophagy相关论文
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-......
Heart aging is characterized by structural and diastolic dysfunction of the heart.However,there is still no effective dr......
Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Park
Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the......
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mi
Parkin,an E3 ubiquitin ligase,plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondr......
ROS-mediated BNIP3-dependent mitophagy promotes coelomocyte survival in Apostichopus japonicus in re
Organisms produce high levels of reactive oxygen species(ROS)to kill pathogens or act as signaling molecules to induce i......
Objective:Mitophagy is known to contribute towards progression of Parkinson\'s disease.Korean red ginseng (KRG) is a w......
Mitochondria play a multidimensional role in the function and the vitality of theneurological system. From the generatio......
Decreased dynamin-related protein 1-related mitophagy induces myocardial apoptosis in the aging hear
An increase in cardiomyocyte apoptosis is the main contributor to the observed high morbid-ity of cardiac disease during......
Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Ne
Patients with diabetes mellitus have a higher risk of developing Parkinson\'s disease (PD).However,the molecular links......
Autophagy is involved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hypert......
Dynamins are large superfamily GTPase proteins that are involved in various cellularpro-cesses including budding of tran......
PINK1 is a mitochondrial serine/threonine kinase,which protects mitochondria from cellular stress and regulates neuronal......
Current pharmacological therapies used in clinical practice for individuals with cardiac, hepatic, renal or pulmonary fi......
Depletion of PINK1 sensitizes breast cancer cells to polyphyllin Ⅰ via mitophagy suppression and DRP
OBJECTIVE To elucidate the molecular mechanism and the anti-breast cancer effect of polyphyllin Ⅰ ,which is a natural c......
Background: Hypoxia is a representative stress environment.When an organisms is subjected to severe hypoxia, many kinds ......
Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumin
Super-resolution optical microscopy has extended the scope of cell biology from the cellular level to the nanoscale,givi......
A Chinese herbal formula, Wuzi Yanzong Pill,improves spermatogenesis by modulating mitophagy of Sert
Objective: To evaluate the effects of the Chinese herbal formula Wuzi Yanzong Pill (WYP) on the spermatogenesis and mito......
Parkin-dependent mitophagy induced by acidic postconditioning extends reperfusion window in focal ce
Prompt reperfusion after cerebral ischemia is critical for neuronal survival.Any strategies extend the limited reperfusi......
Wolfram syndrome (DIDMOAD;WS) is a genetic disorder characterized by diabetes insipidus,diabetes mellitus, optical atrop......
Mitochondria homeostasis is critical for neuronal survival.In ischemic brains,damaged mitochondria lead to neuronal cell......
Selective mitochondrial autophagy in retinal ganglion cells following short-term reduction in cerebr
Purpose Short-term lowering of reduction in cerebrospinal fluid pressure(CSFP)with a disturbance of both the orthograde ......
Objective:Mutations in PINK1 gene cause recessive form of Parkinsons disease (PD).The PINK1 gene encodes a mitochondrial......
Endoplasmic Reticulum Stress Induced by Tunicamycin and Thapsigargin Protects against Transient Isch
Transient cerebral ischemia leads to the endoplasmic reticulum(ER)stress.However,the contributions of ER stress to cereb......
AMPKα-PINK1/parkin-mediated mitophagy involved in human aortic vascular smooth muscle cells prolifer
Vascular smooth muscle cell proliferation is tightly linked to the pathogenesis of vascular proliferative diseases such ......
Background: As an important constituent of atmospheric particulate matter(PM),ultrafine black carbon(uBC)could potential......
Autophagy is a catabolic process for removing aggregated proteins and damaged organelles,of which mitochondria are one o......
Critical hubs of renal ischemia-reperfusion injury: endoplasmic reticulum-mitochondria tethering com
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Involvement of phosphatase and tensin homolog-induced putative kinase 1–Parkin-mediated mitophagy in
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目的观察竹荪多糖（DIP）对亚砷酸钠（NaAsO2）诱导人肝细胞（L-02细胞）中PINK1/Parkin途径介导的线粒体自噬的干预作用。方法将处于对数生长......
Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide (GLP-1)secretion functio
IF1 (ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to con......
Objective To investigate the protective effects and mechanism of Chinese herbal compound Tongxinluo Capsule(通心络胶囊,T......
Intracellular accumulation of tau protein,low energy metabolism and mitochondrial dysfunction are core features in t......
Mitochondria control both the life and death of a cell.To ensure the well-being of the cell,mitochondrial quality an......
BNIP3 is involved in the regulation of cell fate under different hypoxia conditions through the indu
BNIP3 is regulated by hypoxia through hypoxia-inducible factor 1(HIF-1), which binds to hypoxia response element (HR......
Mitophagy, an autophagy-dependent mitochondria-specific degradation pathway conserved from yeast to humans, serves t......
The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming the
Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory fact......
Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation......
线粒体自噬(mitophagy)是指细胞通过自噬的机制选择性地清除线粒体的过程,对于整个线粒体网络的功能完整性十分关键,决定细胞的生......
目的探讨线粒体自噬在呼吸机相关性肺损伤（VILI）中的作用及其机制。方法将36只SPF级SD大鼠按随机数字表法分为自主呼吸组（CON组）、正常......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology,distribu......
Hair loss and gray hair are the ultimate manifestations of scalp and hair aging.Improving metabolic activities in cells ......
Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury
Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.Mitochondrial quality contro......
Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion bra
Mitophagy is a selective form of autophagy involving the removal of damaged mitochondria via the autophagy-lysosome path......
线粒体复合体Ⅱ,也被称为琥珀酸脱氢酶,参与线粒体呼吸作用及代谢重编程的调控过程.复合体Ⅱ由4个亚基构成,其突变与肿瘤的发生密......
目的探讨腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)在肝脏缺血-再灌注损伤(hepatic ischemia-reperfusion injury,H......
细胞线粒体动力学相关功能是指线粒体通过不断地融合与分裂、线粒体自噬及线粒体-内质网结构偶联来维持细胞正常生理功能的过程.其......
Palmitate (PA) exposure induces stress conditions featuring ROS accumulation and upregulation of p62 expression,resultin......
Mitophagy is a degradative pathway that mediates the degradation of the entire mitochondria,and defects in this process ......
