AUTOPHAGY相关论文
目的:探讨耐力训练对帕金森病(Parkinson disease，PD)模型小鼠的保护作用以及通过AMPK/mTOR通路对自噬和外泌体途径的影响。方法:选......
Most people associate the enzyme telomerase with its role in maintaining telomeres, which is its best-known canonical ro......
自噬是细胞在溶酶体的参与下降解自身受损的细胞器及蛋白的过程，对维持细胞内稳态具有重要作用，研究显示自噬功能的失调与食管癌的发......
Ethyl Acetate Fraction of Dicliptera chinensis (L.) Juss.Ameliorates Liver Fibrosis by Inducing Auto
Objective:To investigate the molecular mechanism underlying the anti-hepatic fibrosis activity of ethyl acetate fraction......
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK
β-Elemene is an effective anti-cancer ingredient extracted from the genus Curcuma (Zingiberaceae familiy).In the presen......
A nanocleaner specifically penetrates the blood-brain barrier at lesions to clean toxic proteins and
Insurmountable blood-brain barrier(BBB)and complex pathological features are the key factors affecting the treatment of ......
Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce auto
Protein neddylation is catalyzed by a three-enzyme cascade,namely an E1 NEDD8-activating enzyme(NAE),one of two E2 NEDD8......
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification i
Previous reports suggested that cinnamaldehyde(CA),the bioactive ingredient in Cinnamomum cassia,can suppress tumor grow......
Acetaminophen(APAP)overdose can induce liver injury and is the most frequent cause of acute liver failure in the United ......
AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent
Targeting autophagy might be a promising anticancer strategy;however,the dual roles of autophagy in cancer development a......
Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liv
Metabolic-associated fatty liver disease(MAFLD)is the most common metabolic disease with a global prevalence of 25％.While......
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabeti
Diabetic kidney disease(DKD)is one of the microvascular complications of diabetes mellitus and a major cause of end-stag......
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and a
Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no e......
As a cellular bulk degradation and survival mechanism,autophagy is implicated in diverse biological processes.Genome-wid......
Capsid protein from red-spotted grouper nervous necrosis virus induces incomplete autophagy by inact
As a highly important fish virus,nervous necrosis virus(NNV)has caused severe economic losses to the aquaculture industr......
The biogenesis of autophagosomes provides the basis for macroautophagy to capture and degrade intracellular cargoes.Bind......
创伤性脊髓损伤(SCI)对患者身体和心理健康具有毁灭性的影响。自噬广泛参与机体的各种生理病理过程，在脊髓损伤中发挥关键作用。雷......
Objective::Rubicon is an inhibitory interacting protein of the autophagy-related protein Uvrag. We previously showed tha......
Mechanism of Resveratrol on autophagy mediated by Mst1/Sirt3 signaling pathway in diabetic cardiomyo
Objective: To observe the effects of Resveratrol on myocardial cell injury and Mst1/Sirt3 signaling pathway mediated aut......
Dormant cancer cells that survive anti-cancer therapy can lead to cancer recurrence and disseminated metastases that ult......
目的：:探究高糖诱导体外培养的视网膜Müller细胞自噬及凋亡的变化。方法：:实验研究。将体外培养的SD大鼠视网膜Müller细胞根据不同......
近年来,许多研究发现JNK信号通路能激活下游因子,调节自噬基因的表达,同时它也会影响细胞凋亡.细胞凋亡作为细胞程序性死亡方式之......
目的:探讨间变性淋巴瘤激酶（ALK）阳性间变性大细胞淋巴瘤（ALCL）中自噬介导的克唑替尼耐药对肿瘤干细胞样细胞亚群的影响。方法:本课题......
Tumor necrosis factor receptor-associated factor (TRAF) proteins are conserved in higher eukaryotes and play key roles i......
Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progre
Numerous circular RNAs (circRNAs) have been identified as vital regulators in various cancers.The newly reported circula......
Objective: To investigate the effect of the hexane solvent fraction of Halymenia durvillei (HDHE) on triple-negative bre......
钙稳态失衡和自噬异常是PD、AD及肌萎缩侧索硬化症(ALS)等神经退行性疾病的重要发病机制，二者之间存在相关性。研究显示，细胞不同储......
Sepsis is a pathological process caused by the infection of pathogens such as bacteri-a,viruses,parasites,etc.,which can......
It has been revealed that hypoxia is dynamic in hypertrophic scars;therefore, we considered that it may have different e......
Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following tr
Urolithin A (UA) is a natural metabolite produced from polyphenolics in foods such as pomegranates,berries,and nuts.UA i......
Repurposed anti-cancer epidermal growth factor receptor inhibitors:mechanisms of neuroprotective eff
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the unde......
Bradykinin postconditioning protects rat hippocampal neurons after restoration of spontaneous circul
Bradykinin (BK) is an active component of the kallikrein-kinin system that has been shown to have cardioprotective and n......
目的:评价内侧前额叶皮质(mPFC)小胶质细胞P2Xn 7受体在大鼠神经病理性痛中的作用及其与自噬的关系。n 方法:SPF级健康成......
Autophagy and cancer treatment:four functional forms of autophagy and their therapeutic applications
Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biologica......
β-hydroxy-β-methylbutyrate Improves Chronic Renal Failure-Induced Sarcopenia in SD Rats by Regulatin
Background Chronic renal failure-induced sarcopenia (CRF-S) seriously affects public health by increasing morbidity and ......
Bcl-2 Interacts with Beclin 1 and Regulates Autophagy in 7,12-Dimethylbenz[a]anthracene-Induced Hams
Objective:Autophagy is a programmed cell death procedure,which has essential functions in tumorigenesis.However,its temp......
Background::Sweat secreted by eccrine sweat glands is transported to the skin surface through the lumen. The eccrine swe......
Melanin, DNA replication, and autophagy affect appressorium development in Setosphaeria turcica by r
Setosphaeria turcica (syn. Exserohilum turcicum) is the pathogenic fungus of maize (Zea mays) that causes northern leaf ......
Proteostasis (protein homeostasis) ensures precise adjustment of cellular demand to proteins in the stress conditions,wh......
Parkinson\'s disease (PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the hea......
Natural compounds in the regulation of proteostatic pathways:An invincible artillery against stress,
Cells have different sets of molecules for performing an array of physiological functions.Nu-cleic acids have stored and......
Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a c
RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth.However,monotherapy with glycol......
Resveratrol (RSV) could promote osteogenic activity,but its clinical application has been hampered in view of its poor b......
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Efficacy of Renshen (Radix Ginseng) plus Fuzi (Radix Aconiti Lateralis Preparata) on myocardial infa
OBJECTIVE:To elucidate the protective effects of Renshen (Radix Ginseng) and Fuzi (Radix Aconiti Lateralis Preparata) on......
Salamanders are unique among tetrapods in their ability to regenerate the limbs throughout life.Like other poikilothermi......
Aplastic anemia is a kind of disease mainly manifested by bone marrow failure. Autophagy is very important for cells to ......
Autophagy is an intracellular degradation process that maintains cellular homeostasis. It is essential for protecting or......
背景:自噬对维持细胞稳态和应激敏感性有重要作用,作为细胞清除受损细胞器并实现细胞成分再循环的一种重要方式,在骨代谢中发挥着......
Dynamic changes of autophagy during hypertrophic scar formation and the role of autophagy interventi
Background:The role of autophagy in the formation of hypertrophic scars (HS) remains unclear.This study aimed to explore......
