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目的观察自制六神栓对小鼠白念珠菌阴道炎的治疗作用。方法采用ICR雌性小鼠构建白念珠菌阴道炎模型,随机分为六神栓3个剂量组及生理盐水组和保妇康栓组,每组9只小鼠,采用阴道给药,1次/d,连续7 d,以阴道灌洗载菌量为观察指标。结果各个剂量的六神栓均能降低阴道灌洗液菌落计数,与生理盐水组比较有显著性差异(P<0.05)。随着六神栓治疗剂量的增高,菌落计数逐渐下降,且差异有显著性(P<0.05)。结论六神栓对小鼠白念珠菌阴道炎有治疗作用。
Objective To observe the therapeutic effect of self-made Liushen suppository on Candida albicans vaginitis in mice. Methods The ICR female mice were used to construct C. albicans vaginitis model and randomly divided into three doses of Liushen suppository group and normal saline group and Baofukang suppository group with 9 mice in each group. , For 7 consecutive days, to vaginal lavage inoculated with the amount of observation indicators. Results All doses of Liushen Suppository could reduce the vaginal lavage fluid colonies count, compared with the saline group was significantly different (P <0.05). With the increase of the dose of Liushen suppository, the colony count gradually decreased, and the difference was significant (P <0.05). Conclusion Liushen suppository has therapeutic effects on C. albicans vaginitis in mice.