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为进一步考察鬼臼毒素C_4位取代基侧链的空间取向对分子活性的影响,设计并合成了标题化合物。药理试验提示将其C_4位结构转变为重键官能团,导致抗肿瘤活性减弱。
In order to further investigate the influence of the spatial orientation of the side chain of C_4 substituents on the molecular activity of podophyllotoxin, the title compound was designed and synthesized. Pharmacological tests suggest that the C_4 structure into a key function, resulting in reduced anti-tumor activity.