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目的 探讨老年性系统性红斑狼疮患者的临床特征。方法 总结 5 6例老年性系统性红斑狼疮患者临床表现、自身抗体分布特点及治疗效果 ,并与中青年患者对比分析。结果 老年组蝶形红斑、盘状红斑、光过敏、脱发、雷诺现象等皮肤表现及肾损害和神经系统损害较中青年组明显少见 (P <0 .0 5 ) ,肺部病变、肌痛和肌无力、疲乏明显高于中青年组 ,而血液系统损害和狼疮的两项特异性抗体 (抗ds-DNA和抗Sm抗体 )、非特异性抗体 (抗SS -A和抗SS -B抗体 )以及补体C3 下降的阳性率都低于中青年组 (P <0 .0 5 )。结论 老年性与中青年性系统性红斑狼疮相比在临床表现、实验室检查等方面有其自身特点 ,在临床诊断和治疗中应给予足够重视。
Objective To investigate the clinical features of patients with senile systemic lupus erythematosus. Methods The clinical manifestations, autoantibodies distribution and therapeutic effects of 56 elderly patients with systemic lupus erythematosus were summarized and compared with those of middle-aged and young patients. Results Compared with the young and middle-aged group, the age-related manifestations such as butterfly erythema, discoid erythema, photosensitivity, alopecia, Raynaud’s phenomenon and renal damage and nervous system damage were significantly less than those in the young group (P <0.05) Muscle weakness and fatigue were significantly higher than those in middle-aged and young people. Two specific antibodies (anti-ds-DNA and anti-Sm antibody), non-specific antibodies (anti-SS-A and anti-SS- The positive rate of complement C3 was lower than that of middle-aged group (P <0.05). Conclusion Senile and systemic features of young and middle-aged systemic lupus erythematosus in clinical manifestations, laboratory tests and other aspects of its own characteristics, in clinical diagnosis and treatment should be given enough attention.