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目的:探讨在乳腺癌病理组织中瘦素表达与凋亡调节因子Survivin、Bcl-2和BAX表达的相关性。方法:选取首都医科大学附属北京友谊医院普外科2003-01-2005-01,接受手术切除的102例乳腺癌患者的组织标本蜡块,免疫组织化学方法测定组织中Leptin和Sur-vivin、Bcl-2、BAX的表达。统计分析leptin与Survivin、Bcl-2、BAX在乳腺癌组织中表达的相关性,以及它们与乳腺癌临床病理特征的相关性。结果:瘦素在乳腺癌中表达与肿瘤大小(r=0.246,P=0.013)、淋巴结转移(r=0.209,P=0.035)和远处转移(r=0.215,P=0.030)呈正相关;Survivin在乳腺癌组织中表达与肿瘤大小(r=0.313,P=0.001)、远处转移(r=0.204,P=0.040)呈正相关;Bcl-2在乳腺癌组织中表达与肿瘤大小(r=0.246,P=0.013)、淋巴结转移(r=0.287,P=0.003)呈正相关。瘦素与Survivin(r=0.247,P=0.012)、Bcl-2(r=0.230,P=0.020)在乳腺癌组织中表达呈正相关。结论:在乳腺癌组织中,瘦素的表达与凋亡调节因子Survivin、Bcl-2的表达呈正相关,瘦素可能通过调节凋亡因子的表达影响乳腺癌的发生进展。结论:在乳腺癌组织中,瘦素的表达与凋亡调节因子Survivin、Bcl-2的表达呈正相关,瘦素可能通过调节凋亡因子的表达影响乳腺癌的发生进展。
OBJECTIVE: To investigate the correlation between leptin expression and the expression of Survivin, Bcl-2 and BAX in breast cancer pathological tissues. Methods: A total of 102 cases of breast cancer patients undergoing surgical resection were enrolled in the Department of General Surgery, Beijing Friendship Hospital Affiliated to Capital Medical University from January 2003 to January 2005. The expressions of Leptin, Survivin and Bcl- 2, BAX expression. The correlation between the expression of leptin and Survivin, Bcl-2 and BAX in breast cancer tissues was statistically analyzed and their correlation with the clinicopathological features of breast cancer was analyzed. Results: The expression of leptin in breast cancer was positively correlated with tumor size (r = 0.246, P = 0.013), lymph node metastasis (r = 0.209, P = 0.035) and distant metastasis The expression of Bcl-2 in breast cancer was positively correlated with tumor size (r = 0.313, P = 0.001) and distant metastasis (r = 0.204, P = 0.040) , P = 0.013), lymph node metastasis (r = 0.287, P = 0.003). Leptin was positively correlated with the expression of Survivin (r = 0.247, P = 0.012) and Bcl-2 (r = 0.230, P = 0.020) in breast cancer tissues. Conclusion: The expression of leptin is positively correlated with the expression of Survivin and Bcl-2 in breast cancer. Leptin may influence the occurrence of breast cancer by regulating the expression of apoptosis factor. Conclusion: The expression of leptin is positively correlated with the expression of Survivin and Bcl-2 in breast cancer. Leptin may influence the occurrence of breast cancer by regulating the expression of apoptosis factor.