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目的:探讨种植窗口期子宫内膜中MMP-9、TIMP-1和ICAM-1的表达及其与体外受精-胚胎移植妊娠结局的关系。方法:收集40例拟行IVF/ICSI-ET妇女前1周期黄体中期的子宫内膜组织,分别检测妊娠组与非妊娠组中MMP-9、TIMP-1及ICAM-1的表达。结果:与妊娠组相比,非妊娠组中MMP-9、TIMP-1及ICAM-1的表达显著降低,差异有显著性(P<0.05)。结论:种植窗口期子宫内膜中MMP-9、TIMP-1及ICAM-1表达降低,影响胚胎的着床,降低妊娠率,可作为预测IVF/ICSI-ET妊娠结局的指标之一。
OBJECTIVE: To investigate the expression of MMP-9, TIMP-1 and ICAM-1 in the endometrium of implantation window and its relationship with the pregnancy outcome of in vitro fertilization-embryo transfer. Methods: Forty cases of endometrial tissues in the first luteal phase of IVF / ICSI-ET women were enrolled in this study. The expressions of MMP-9, TIMP-1 and ICAM-1 in pregnant women and non-pregnant women were detected respectively. Results: Compared with pregnancy group, the expression of MMP-9, TIMP-1 and ICAM-1 in non-pregnancy group was significantly lower than that in pregnancy group (P <0.05). Conclusions: The decreased expression of MMP-9, TIMP-1 and ICAM-1 in the endometrium during implantation may affect the embryo implantation and reduce the pregnancy rate, which may be used as an index to predict the pregnancy outcome of IVF / ICSI-ET.