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目的探讨人乳头状瘤病毒(HPV)检测在宫颈病变诊断中的临床意义以及HPV负荷量与宫颈病变组织病理学改变的相关性。方法对解放军总医院妇科门诊2350名患者行宫颈TCT和高危型HPV检测,并对TCT异常患者行阴道镜下宫颈组织病理学检查。结果将HPV负荷量由低至高行数量分级后,病理结果异常率分别为10.11%、31.75%、41.38%、53.02%和54.23%。结论宫颈病变发生率及严重程度与病毒负荷量密切相关,随着病毒负荷量增加,宫颈病变发生率增加,其病变程度也相应加重。
Objective To investigate the clinical significance of human papillomavirus (HPV) detection in the diagnosis of cervical lesions and the correlation between HPV load and histopathological changes of cervical lesions. Methods Cervical TCT and high-risk HPV were detected in 2350 gynecological outpatients in PLA General Hospital and colposcopic examination of cervical tissue pathology was performed on patients with abnormal TCT. Results The abnormal rates of pathological results were 10.11%, 31.75%, 41.38%, 53.02% and 54.23%, respectively, after grading the number of HPV load from low to high. Conclusions The incidence and severity of cervical lesions are closely related to the viral load. With the increase of viral load, the incidence of cervical lesions increases, and the severity of cervical lesions also increases accordingly.