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近年来体外实验表明PPARγ受体激动剂有抗肿瘤的作用,动物实验也证明了这一点。另外,在对脂肪肉瘤及前列腺癌患者的临床研究中,也观察到了PPARγ受体激动剂的抗肿瘤作用。本文就PPARγ激动剂的抗肿瘤作用及其信号传导通路做一综述。
In vitro experiments in recent years show that PPARγ receptor agonists have antitumor effects, animal experiments have proved this point. In addition, anti-tumor effects of PPARγ receptor agonists have also been observed in clinical studies on liposarcoma and prostate cancer patients. This article reviews the anti-tumor effects of PPARγ agonists and their signaling pathways.