【摘 要】
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In insects,20-hydroxyecdysone (20E) limits systemic growth by triggering developmental transitions.Previous studies have shown that 20E-induced let-7 exhibits crosstalk with the cell cycle.Here,we examined the underlying molecular mechanisms and physiolog
【机 构】
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Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology,Institute
论文部分内容阅读
In insects,20-hydroxyecdysone (20E) limits systemic growth by triggering developmental transitions.Previous studies have shown that 20E-induced let-7 exhibits crosstalk with the cell cycle.Here,we examined the underlying molecular mechanisms and physiological functions of 20E-induced let-7 in the fat body,an organ for energy stor-age and nutrient mobilization which plays a critical role in the larval growth.First,the overexpression of let-7 decreased the body size and led to the reduction of both nucleolus and cell sizes in the larval fat body.In contrast,the overexpression of let-7-Sponge in-creased the nucleolus and cell sizes.Moreover,we found that cdc7,encoding a conserved protein kinase that controls the endocycle,is a target of let-7.Notably,the mutation of cdc7 in the fat body resulted in growth defects.Overall,our findings revealed a novel role of let-7 in the control of endoreduplication-related growth during larval-prepupal transition in Drosophila.
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