【摘 要】
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Natural biopolymers have excellent biocompatibility and biodegradability;they can be used as biomedical materials for wound healing.In this work,the Silk Fibroin(SF)and K-carrageenan(κ-Car)composite films containing Zinc-doped Bioac-tive Glass(ZBG)have be
【机 构】
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School of Materials Science and Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China;Depar
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Natural biopolymers have excellent biocompatibility and biodegradability;they can be used as biomedical materials for wound healing.In this work,the Silk Fibroin(SF)and K-carrageenan(κ-Car)composite films containing Zinc-doped Bioac-tive Glass(ZBG)have been fabricated for wound closure applications.The as-fabricated SF-κ-Car/ZBG composite films have excellent stretchability and foldability,which facilitates them for application as wound dressing.They also exhibit excellent hydrophilicity and water-absorption capacity,which can effectively absorb wound exudate and keep the wound sites under moist state.In addition,the composite films have a good antibacterial effect against S.aureus and E.coli in vitro,which can reduce the risk of wound infection.Their excellent cell compatibility is confirmed by the CCK-8 assay.The strong vascular proliferation and wound regeneration are found in SF-κ-Car/ZBG composite films on a mouse skin wound model.The SF-κ-Car/ZBG composite films can inhibit the secretion of inflammatory factors,and stimulate the production of vascular factors and collagen fibers.The results derived from the performed investigations revealed that the SF-κ-Car/ZBG composite films are a promising candidate dressing for wound healing applications.
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