Purpose: To describe a case of corneal abscess caused by Fusarium solani that did not respond to common antifungal agents. Method: Case report. Results: Twent y days after accidental contact with vegetation, a 56-year-old man presented w ith a corneal abscess. Corneal ulceration developed and a perforating keratoplas ty was performed. After a microbiological examination, the diagnosis of F. solan i infection was made. Systemic and topical amphotericin B and fluconazole were p rescribed, with no results. A new abscess formed on the transplanted graft and a wound leak developed. We administered topical and systemic voriconazole. No sid e-effects were observed. The choroidal detachment and the surgical transplant r ecovered completely in 20 days. A vascular leukoma developed at the site of the transplanted corneal abscess. Conclusion: From a functional point of view, anoth er corneal transplant will be necessary. Voriconazole was effective in treating a severe keratomycosis caused by F. solani that was resistant to other topical a nd systemic antifungal agents. Purpose: To describe a case of corneal abscess caused by Fusarium solani that did not respond to common antifungal agents. Method: Case report. Results: Twent y days after accidental contact with vegetation, a 56-year-old man presented w ith a corneal After a microbiological examination, the diagnosis of F. solan i infection was made. Systemic and topical amphotericin B and fluconazole were p rescribed, with no results. A new abscess formed on the No sid e-effects were observed. The choroidal detachment and the surgical transplant r ecologically completely in 20 days. A vascular leukoma developed at the site of the transplanted corneal abscess. Conclusion: From a functional point of view, anoth er corneal transplant will be necessary. Voriconazole was effective in treating a severe keratomycosis caused by F. s olani that was resistant to other topical a nd systemic antifungal agents.