【摘 要】
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Disulfide (DSF) has been proved good anti-tumor effect and even better with coadministration of Cu2+.In this work,we report the use of hyaluronic acid (HA) based materials to construct vectors for the delivery of both DSF and Cu2+.HA was firstly modified
【机 构】
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Institute of Biomedical Materials and Engineering,College of Chemistry and Chemical Engineering,Coll
论文部分内容阅读
Disulfide (DSF) has been proved good anti-tumor effect and even better with coadministration of Cu2+.In this work,we report the use of hyaluronic acid (HA) based materials to construct vectors for the delivery of both DSF and Cu2+.HA was firstly modified with polyethylene glycol monomethyl ether (mPEG) and polycaprolactone (PCL) to synthesize an amphiphilic polymer (HA-PEG-PCL).DSF could be loaded in the hydrophobic core and Cu2+ could be cooperated to the negative hydrophtilic segment.The Cu2+ also played a role as crosslinking agent,which prevented DSF leakage prematurely,avoiding the bad side effects to normal tissues.The interaction between HA and CD44 improved the distribution ofnanodrugs in tumor cells.When the nanodrugs were delivered to the cancer cell,the acidic micro-environment would separate the Cu2+ from the surface,leading to the disintegration of the micelles,promoting the release of DSF from the micelle core.The results of in vitro and in vivo experiments showed that the DSF and Cu2+ co-delivery vector constructed in this work could enhance the antitumor effect and have low biological toxicity.
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