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Sl突变和W突变小鼠具有相同的症状,但突变导致的缺陷不同。W突变导致造血细胞本身缺陷;而Sl突变影响造血微循环。证实w位点编码膜受体C-Kit后,又发现C-Kit的配体是Sl位点编码的一种新的造血因子。本文综述这种新造血因子的结构及生物学活性。
Sl mutants and W mutants have the same symptoms, but the mutations cause different defects. W mutation leads to defects of hematopoietic cells itself; while mutation of Sl affects hematopoietic microcirculation. After confirming that the W site encodes the membrane receptor C-Kit, the ligand of C-Kit was found to be a new hematopoietic factor encoded by the Sl site. This article reviews the structural and biological activities of this new hematopoietic factor.