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中药单体淫羊藿甙是一种新型的生物反应调节剂和诱导分化剂。为进一步探讨淫羊藿甙抗癌作用机制,我们将淫羊藿甙作用于人高转移肺癌细胞PG,采用MTT、放免、流式细胞术。粘附实验。运动侵袭实验等多种手段进行了检测。结果表明,淫羊藿甙虽直接抑癌作用较弱,但却能影响PG细胞周期的时相分布,使S期减小,并能升高细胞内cAMP水平,降低cGMP水平,提高cAMP/cGMP比值,同时降低PG细胞对胞外基质的粘附性及侵袭、运动能力,从而逆转肿瘤细胞的恶性表型。提示,淫羊藿甙作为一种有开发前景的抗肿瘤药物值得进一步深入研究。
Chinese Herbal Epimedium is a novel biological response modifier and inducer. To further explore the anti-cancer mechanism of epimedium, we used epimedium to act on human high-metastatic lung cancer cells, using MTT, radioimmunoassay, and flow cytometry. Adhesion experiments. Sports invasive experiments and other means were tested. The results showed that although Epimedium has a weaker direct anti-cancer effect, it can affect the phase distribution of PG cell cycle, reducing the S phase, and can increase intracellular cAMP levels, reduce cGMP levels, and increase cAMP/cGMP. The ratio reduces the adhesion and invasion of PG cells to the extracellular matrix and their exercise capacity, thereby reversing the malignant phenotype of the tumor cells. Tips, Epimedium as a promising anti-cancer drugs worth further study.