帕金森病(Parkinson disease,PD)是病因未明、老年期常见的神经变性病,主要病理基础为黑质致密部多巴胺(do-pamine,DA)能神经元变性、缺失和残存神经元胞浆中出现路易小体(Lewy body)。累积的证据显示,氧化应激、线粒体功能障碍、神经营养因子下调、钙超载、兴奋性氨基酸毒性作 Parkinson’s disease (PD) is a neurodegenerative disease with unknown etiology and common in old age. The main pathological basis is degeneration, deletion and residual neuronal cytoplasm of dopaminergic neurons in the substantia nigra pars compacta Lewy body appears. Accumulating evidence suggests that oxidative stress, mitochondrial dysfunction, downregulation of neurotrophic factors, calcium overload, and excitatory amino acid toxicity