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在国家“523”(防治疟疾新药项目代号)任务实施50周年之际,对广州中医药大学青蒿素抗疟研究科研团队采用青蒿素复方防治疟疾的历程与所取得的进展进行评述。广州中医药大学作为“523”项目研究小组之一,其青蒿素抗疟研究科研团队相继主持了采用青蒿素及其衍生物不同剂型、剂量、疗程治疗疟疾的临床研究(1974~1989)、青蒿素复方(Artekin及Artequick)治疗疟疾的临床研究(1984~2006),并于近10年中在东南亚地区及非洲全力推行快速消灭传染源清除疟疾(Fast Elimination of Malaria by Source Eradication,FEMSE)的抗疟项目。青蒿素抗疟研究科研团队所做的探索与获得的成就为青蒿素类药物走向世界做出了重要贡献,并为全球快速消灭疟疾创建了一种简单、易行、省钱的新方法。
On the occasion of the 50th anniversary of the implementation of the national “523” (code name for prevention and treatment of malaria) project, the article reviewed the history and progress of the artemisinin compound malaria research and treatment team of Guangzhou University of Chinese Medicine . Guangzhou University of Chinese Medicine as one of the “523 ” project research team, its artemisinin antimalarial research team has presided over the use of artemisinin and its derivatives in different forms, doses, treatment of malaria clinical study (1974 ~ 1989), artemisinin (Artekin and Artequick) for the treatment of malaria (1984-2006), and in the recent 10 years in South East Asia and Africa to promote the rapid elimination of malaria by Source of Elimination (Fast Elimination of Malaria by Source Eradication , FEMSE) antimalarial project. The discoveries and achievements made by the artemisinin malaria research team have made a significant contribution to the world-class introduction of artemisinin and created a new simple, easy and cost-effective way to rapidly eliminate malaria worldwide .