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目的观察奥扎格雷钠联合低分子肝素钙治疗脑梗死的疗效。方法120例早期脑梗死患者采用随机分组为治疗组和对照组,两组均予常规对症治疗(包括脱水降颅内压、扩容、降血压、改善脑循环等),治疗组加用奥扎格雷钠及低分子肝素钙,用药14d,对两组患者治疗后的意识状态好转的起效时间及神经功能缺损评分,临床疗效的总有效率,血液流变学指标进行比较。结果治疗组、临床疗效的总有效率优于对照组(p<0.01),治疗后血液流变学指标明显改善(p<0.01).结论奥扎格雷钠联合低分子肝素钙治疗早期脑梗死有较好的效果,且无明显不良反应.治疗组总有效率为95%,对照组总有效率为75%。症状及体征明显改善,瘫痪肌力提高,生活部分自理,住院时间明显缩短,且安全性好,值得推广.
Objective To observe the curative effect of sodium ozagrel combined with low molecular weight heparin on cerebral infarction. Methods One hundred and twenty patients with early cerebral infarction were randomly divided into treatment group and control group. Both groups were given conventional symptomatic treatment (including dehydration and intracranial pressure, dilatation, blood pressure lowering and cerebral circulation improvement). Patients in treatment group were given ozagrel Sodium and low-molecular-weight heparin calcium were used for 14 days. The onset time, the neurological deficit score, the total effective rate of clinical curative effect, and the hemorheology indexes of two groups of patients after treatment were compared. Results In the treatment group, the total effective rate of clinical curative effect was better than that of the control group (p <0.01), and the indexes of hemorheology were significantly improved after treatment (p <0.01) .Conclusion Ozagrel sodium and low molecular weight heparin calcium treatment of early cerebral infarction Good effect, and no obvious adverse reactions.The total effective rate was 95% in the treatment group, the control group, the total effective rate was 75%. Symptoms and signs improved significantly, improved muscle strength paralysis, self-care part of life, significantly shorter hospital stay, and good safety, it is worth promoting.