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花生四烯酸级联反应中的前列腺素(PG)、血栓素(TX)和白三烯(LT)是肺部疾病中起重要作用的物质。研究这些物质的历史较久,始于30年代。但在其后的30年,由于机体内PG含量甚微,代谢非常迅速,所以,对PG的研究进展不大。60年代以来,Bergstrm确定了PGE与PGF系统的结构。后来,临床用PGE_1治疗末梢动脉阻塞,用PGF_(2a)促进子宫收缩。70年代,关于PG的研究取得飞速的进展。Samuelsson和Vane又确定了TXA_2、前列环素(PGI_2)及LT的结构,它们的药理作用也正在阐明中。肺扩张、低氧血症和各种血管活性物质的刺激,或者由于变态反应等原因,呼吸系统的PG类(PGE_2,PGF_(2a),PGI_2),TXA_2以及LT类(LTB_4,LTC_4,LTD_4,LTE_4)的
Prostaglandin (PG), thromboxane (TX), and leukotriene (LT) in the arachidonic acid cascade are substances that play an important role in pulmonary disease. The study of these substances has a long history, beginning in the 1930s. However, in the next 30 years, due to the small amount of PG in the body, the metabolism is very rapid, so little progress has been made on PG. Since the 1960s, Bergstrm has identified the structure of PGE and PGF systems. Later, clinical PGE_1 treatment of peripheral artery occlusion, with PGF_ (2a) to promote uterine contractions. In the 1970s, research on PG progressed rapidly. Samuelsson and Vane identified the structures of TXA_2, PGI_2 and LT, and their pharmacological actions are also being elucidated. (PGE_2, PGF_ (2a), PGI_2), TXA_2, and LT (LTB_4, LTC_4, LTD_4, and LTB_4) in the respiratory system due to the stimulation of pulmonary vasodilation, hypoxemia and various vasoactive substances, LTE_4)