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目的探讨白质脑病的病因、临床表现以及MRI影像学特点。方法回顾分析我院2009年12月~2010年3月53例白质脑病患者的临床及影像资料。结果本组白质脑病病因为血管性白质脑病31例,多发性硬化8例,可逆性后部白质脑病6例,一氧化碳中毒性脑病4例,艾滋病痴呆综合征、肾上腺脑白质营养不良各1例,未能明确病因2例。临床表现以认知障碍、偏瘫及抑郁等精神异常为主;MRI表现为双侧脑室周边及半卵圆中心对称的片状或融合的长T1、长T2信号。结论白质脑病病因复杂,患者均有不同程度的认知障碍,MRI对诊断脑白质病敏感性高,有重要的临床参考价值。
Objective To investigate the etiology, clinical manifestations and MRI features of leukoencephalopathy. Methods Retrospective analysis of our hospital from December 2009 to March 2010 53 cases of leukoencephalopathy in patients with clinical and imaging data. Results The etiology of leukoencephalopathy in this group was 31 cases of vascular leukoencephalopathy, 8 cases of multiple sclerosis, 6 cases of reversible posterior leukoencephalopathy, 4 cases of carbon monoxide poisoning encephalopathy, AIDS dementia syndrome, 1 case of adrenoleukodystrophy, 2 cases failed to identify the cause. The main clinical manifestations were cognitive disorders, hemiparesis and depression and other mental disorders; MRI showed bilateral periventricular and semi-oval center symmetrical flaky or fusion of long T1, long T2 signal. Conclusions The etiology of white matter encephalopathy is complicated. All patients have different degrees of cognitive impairment. MRI is of high sensitivity in the diagnosis of leukoencephalopathy and has important clinical reference value.