DNA damage is one of the most important consequences of oxidative stress in the cells.If DNA repair is unable to modify these inducible DNA damages,genomic instability may lead to mutation,cancer,aging and many other diseases.Single cell gel electrophoresis or comet assay is a common and versatile method to quantify these types of DNA damages.DNA damages induced by hydrogen peroxide (H2O2) are one of the proper models for measurement of protective ability of different compounds.So the main aim of this review is to provide an overview about protection ability of medicinal plants and their potential mechanism against H2O2 induced DNA damages.In this review,relevant researches on the effect of medicinal plants on DNA damages induced by H2O2 and possible molecular mechanisms are discussed.It seems that,medicinal plants are considered as therapeutic key factors to protect DNA from consequences caused by oxidative stress.Sufficientin vitro evidences introduce them as DNA protective agents through different mechanisms including antioxidant activity and some other cellular mechanisms.Moreover,in order to correlate the antigenotoxicity effects with their potential antioxidant property,most of medicinal plants were evaluated in term of antioxidant activity using standard methods.This review highlights the preventive effects of herbal medicine against oxidative DNA damages as well as provides rational possibility to engage them in animal studies and future clinical investigations.