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目的探索腹腔循环热灌注联合化疗在治疗晚期胃癌合并腹腔积液中的有效性和安全性。方法 96例晚期胃癌合并腹腔积液患者,随机分为对照组和观察组,每组48例。对照组患者单一采用化疗治疗,观察组患者给予腹腔循环热灌注联合化疗治疗。对比两组患者的治疗效果。结果观察组患者的治疗有效率为62.50%,高于对照组的41.67%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为20.83%,低于对照组的39.58%,差异具有统计学意义(P<0.05)。结论腹腔循环热灌注联合化疗治疗晚期胃癌合并腹腔积液效果确切,且安全性高,有助于提高患者的生存质量,值得推广。
Objective To explore the effectiveness and safety of intraperitoneal hyperthermic perfusion combined with chemotherapy in the treatment of advanced gastric cancer complicated with ascites. Methods 96 cases of advanced gastric cancer with ascites were randomly divided into control group and observation group, 48 cases in each group. Patients in the control group were treated with chemotherapy alone, while patients in the observation group were given intraperitoneal hyperthermic perfusion combined with chemotherapy. Compare the treatment effect of two groups of patients. Results The effective rate of treatment in observation group was 62.50%, which was higher than that in control group (41.67%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 20.83%, which was lower than that in the control group (39.58%), the difference was statistically significant (P <0.05). Conclusion Intraperitoneal hyperthermic perfusion combined with chemotherapy for the treatment of advanced gastric cancer combined with ascites has the exact effect and high safety, which is helpful to improve the quality of life of patients and is worthy of popularization.