妊娠相关血浆蛋白-A最先是从孕妇血清中分离出来的一种与妊娠相关联的大分子糖蛋白,后来发现它是一种与胰岛素样生长因子相关的锌结合金属蛋白酶。新近发现妊娠相关血浆蛋白-A是一种新型炎症标记物,参与动脉粥样硬化的发生发展,并且与斑块的不稳定性关系密切,在不稳定的粥样斑块中大量表达,对识别不稳定斑块有着非常重要的作用。 Pregnancy-associated plasma protein-A was first isolated from maternal serum, a pregnancy-associated macromolecular glycoprotein, which was later found to be a zinc-binding metalloproteinase associated with insulin-like growth factor. Recently, pregnancy-related plasma protein-A is a new type of inflammatory marker, which is involved in the development of atherosclerosis. It is closely related to plaque instability and is expressed in unstable atherosclerotic plaques. Unstable plaque has a very important role.