After M_W 7.8 Nepal earthquake occurred, the rearrangement of stresses in the crust commonly leads to subsequent damaging earthquakes. We present the calculations of the coseismic stress changes that resulted from the 25 th April event using models of regional faults designed according to south Tibet-Nepal structure, and show that some indicative significant stress increases. We calculate static stress changes caused by the displacement of a fault on which dislocations happen and an earthquake occurs. A M_W 7.3 earthquake broke on 12 May at a distance of * 130 km SEE of the M_W 7.8 earthquake, whose focus roughly located on high Coulomb stress change(CSC) site. Aftershocks(first 15 days after the mainshock)are associated with stress increase zone caused by the main rupture. We set receiver faults with specified strikes, dips,and rakes, on which the stresses imparted by the source fault are resolved. Four group normal faults to the north of the Nepal earthquake seismogenic fault were set as receiver faults and variant results followed. We provide a discussion on Coulomb stress transfer for the seismogenic fault, which is useful to identify potential future rupture zones. After M_W 7.8 Nepal disaster occurred, the rearrangement of stresses in the crust generally leads to subsequent damaging earthquakes. We present the calculations of the coseismic stress changes that resulted from the 25 th April event using models of regional faults designed according to south Tibet-Nepal structure, and show that some abnormal significant stress increases. We calculate static stress changes caused by the displacement of a fault on which dislocations happen and an earthquake occurs. M_W 7.8 earthquake, whose focus roughly located on high Coulomb stress change (CSC) site. Aftershocks (first 15 days after the mainshock) are associated with stress increase zone caused by the main rupture. We set receiver faults with specified strikes, dips, and rakes, on which the weight imparted by the source fault are resolved. Four group normal faults to the north of the Nepal earthquake seismogenic fault were se t as receiver faults and variant results followed. We provide a discussion on Coulomb stress transfer for the seismogenic fault, which is useful to identify potential future rupture zones.