论文部分内容阅读
IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against infection.Although CD4+helper T lymphocytes(TH)were found as a source of IL-22,the regulation of this cytokine has beenpoorly understood.Here,we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of THcells that also makes IL-17.IL-22 and IL-17 were found to be coordinately regulated by TGFβ and IL-6 during TH dif-ferentiation by real-time PCR as well as ELISA analysis.However,IL-22 does not regulate TH differentiation; exogenousIL-22 or an IL-22 antagonist had no effect on TH differentiation.These data demonstrate a novel cytokine expressed byIL-17-producing T cells,and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflam-mation and autoimmune diseases.
IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of the tissues against infection. Although CD4 + helper T lymphocytes (TH) were found as a source of IL-22, the regulation of this cytokine has beenpoorly understood. Here, we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of TH cells that also makes IL-17. IL-22 and IL-17 were found to be coordinately regulated by TGFβ and IL-6 during TH dif-ferentiation by real-time PCR as well as ELISA analysis. However, IL-22 does not regulate TH differentiation; exogenous IL-22 or an IL-22 antagonist had no effect on TH differentiation. The data demonstrate a novel cytokine expressed by IL-17-producing T cells, and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflammations and autoimmune diseases.