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近年来基因疗法发展迅速，减毒沙门菌介导的真核表达载体防治应激性溃疡的基因治疗方法已经逐步从实验及基础研究过渡到临床试用阶段，理论和技术层次上日趋成熟。而基于低氧诱导因子1α与角质细胞生长因子防治应激性溃疡的研究现状一直缺乏整理与总结，该文整理了携带双基因的重组减毒沙门菌的实现情况及存在问题，为进一步研究提供帮助。“,”At present gene therapy has developed rapidly.Gene therapy containing the eukaryotic expression vector of attenuated Salmonella has gradually transited from experiment and basic research to clini-cal trial stage in prevention and treatment of stress ulcer,and the theory and technology level are more and more mature.However,the keratinocyte growth factor and hypoxia-inducible factor 1α-based research of pre-vention of stress ulcer has been lacking of finishing with summary.Here is to summarize the achievement and problems of recombinant Salmonella carrying double genes to help the further research .