论文部分内容阅读
小白鼠１３６只，随机分为①小白鼠肝叶结扎组（ｎ＝５３）；②肝叶假结扎组（ｎ＝５３）；③肝叶结扎＋生理盐水（ＮＳ）组（ｎ＝３０）。３组小白鼠乙醚全麻、开腹、结扎和假结扎大部分肝叶，①、②组均从肠腔插管注入８０ｇ／Ｌ氯化按（ＮＨ＿４Ｃｌ），③组同法注入等量ＮＳ；另对８６只小白鼠腹腔直接注射８０ｇ／ＬＮＨ＿４Ｃｌ０．０１Ｌ／ｋｇ，随机分为谷氨酸钠抢救组（ｎ＝４３）和ＮＳ对照组（ｎ＝４３）。结果：小白鼠出现典型的氨中毒症状，表现为：躁动、抽搐、呼吸异常、四肢强直、重至死亡；与肝叶假扎组相比，肝叶真扎组所用ＮＨ＿４Ｃｌ剂量少，氨中毒症状出现早，死亡时间早，两组均有显著性差异（Ｐ＜０．０１）；用谷氨酸钠抢救，明显延长氨中毒小白鼠的生存时间（Ｐ＜０．０１）。提示：用小白鼠可复制肝性脑病的氨中毒疾病模型和进行实验性的治疗。
One hundred and sixty-six mice were randomly divided into 1 group (n = 53); (2) liver ligation group (n = 53), liver ligation + NS group (n = 30). The rats in the three groups were given ether anesthesia, laparotomy, ligation and fake ligation of most of the liver lobes. ① and ② groups were injected with 80g / L chlorinated (NH_4Cl) Another 86 mice were injected intraperitoneally with 80g / LNH_4Cl0.01L / kg, and were randomly divided into sodium glutamate rescue group (n = 43) and NS control group (n = 43). Results: The symptoms of typical ammonia poisoning in mice were as follows: restlessness, convulsions, abnormal breathing, straightness of the limbs and death to heavy death. Compared with the hepatic lobectomy group, There was a significant difference between the two groups (P <0.01). The treatment with sodium glutamate prolonged the survival time of mice with ammonia poisoning (P <0.01). Tip: mouse white mice can replicate hepatic encephalopathy ammonia poisoning disease model and experimental treatment.