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本研究包括10名有正常排卵周期的健康妇女,年龄为22～34岁,研究前至少4个月未使用过甾体避孕药。研究包括3个连续周期,第一、三周期所有对象均不用药(对照周期),第二周期的第一至十四天5例每天肌注HOE766〔D-ser(TBU)~6-LHRH-(1-9)-nonapeptide-ethylamide〕10μg,另5例每天肌注安慰剂,所有对象记录基础体温(BBT),于用药周期的第一、二、三天在注射HOE766或安慰剂之前及注射后4小时,在第七,十二、十三及十四天于注射后4小时分别取静脉血用放射免疫法(RIA)测定血清LH、FSH、雌
This study included 10 healthy women who had a normal ovulation cycle, aged 22-34 years, and had not taken any steroid contraceptives for at least 4 months prior to the study. The study included 3 consecutive cycles, with no medication in the first and third cycles (control cycle), and five daily intramuscular HOE766 [D-ser (TBU) to 6-LHRH- (1-9) -nonapeptide-ethylamide 〔〕 〔〕 〔〕 〔〕, and the other 5 cases of placebo daily intramuscular injection, all subjects recorded basal body temperature (BBT) in the first, second and third days of the drug cycle before injection of HOE766 or placebo and injection Four hours after the injection, venous blood was taken at 4, 4 hours after the seventh, the twelfth, the thirteenth, and the fourteen days after the injection, respectively. Serum LH, FSH, and FSH were measured by radioimmunoassay (RIA)