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目的观察分析卵巢过度刺激综合征(OHSS)高风险患者行新鲜胚胎移植和冻融胚胎移植辅助妊娠后的临床效果。方法选取体外受精(IVF)及卵胞浆内单精子显微注射技术(ICSI)周期诊断为OHSS高风险的不孕患者130例,在给患者充分知情同意后由其选择新鲜胚胎移植或全胚冷冻后择期冻胚移植,分为鲜胚组67例和冻胚组63例,对比分析行不同移植技术后患者妊娠结局、新生儿质量和OHSS发病率方面的差异。结果对于OHSS高风险患者,冻胚组的种植率、妊娠率、活产率明显高于鲜胚组(P<0.05或P<0.01),而且OHSS发生率明显低于鲜胚组(P<0.05),早产率明显低于鲜胚组(P<0.05)。结论对于OHSS高危患者,应该采用全胚冷冻,再择期行冻胚移植,有助于提高胚胎移植的临床妊娠率、种植率与活产率,同时能降低OHSS患病率与早产儿发生率,值得临床推广应用。
Objective To investigate the clinical effect of fresh embryo transfer and frozen-thawed embryo transfer in high-risk patients with ovarian hyperstimulation syndrome (OHSS). Methods In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycle diagnosed as high risk of OHSS in 130 cases of infertility, patients with full informed consent by their choice of fresh embryo transfer or whole embryo Frozen frozen embryo transfer, divided into fresh embryo group 67 cases and frozen embryo group 63 cases, comparative analysis of the different grafting techniques in patients with pregnancy outcome, neonatal quality and OHSS morbidity differences. Results The implantation rate, pregnancy rate and live birth rate of frozen-embryo group were significantly higher than those of fresh embryo group (P <0.05 or P <0.01), and the incidence of OHSS was significantly lower than that of fresh embryo group (P <0.05) ), Premature birth rate was significantly lower than the fresh embryo group (P <0.05). Conclusions For high-risk patients with OHSS, whole-embryo freezing should be used and then frozen-embryo transfer should be performed. It is helpful to improve the clinical pregnancy rate, implantation rate and live birth rate of embryo transfer, and reduce the prevalence of OHSS and the incidence of premature infants. Worthy of clinical application.