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The rapid rise of chemical biology aimed at studying signaling networks for basiccellular activities using specific,active small molecules as probes has greatlyaccelerated research on pathological mechanisms and target therapy of diseases.This research is especially important for malignant tumors such as leukemia,aheterogeneous group of hematopoietic malignancies that occurs worldwide.Withthe use of a chemical approach combined with genetic manipulation,great progresshas been achieved over the past few decades on the biological,molecular andcytogenetic aspects of leukemia,and in its diagnosis and therapy.In particular,discoveries of the clinical effectiveness of all-trans retinoic acid and arsenictrioxide in the treatment of acute promyelocytic leukemia and the kinase inhibitorsImatinib and Dasatinib in the treatment of chronic myelogenous leukemia not onlymake target therapy of leukemia a reality,but also push mechanisms of leukemo-genesis and leukemic cell activities forward.This review will outline advances inchemical biology that help our understanding of the molecular mechanisms of celldifferentiation and apoptosis induction and target therapy of leukemia.
The rapid rise of chemical biology aimed at studying signaling networks for basiccellular activities using specific, active small molecules as probes has greatlyaccelerated research on pathological mechanisms and target therapy of diseases. This research is especially important for malignant tumors such as leukemia, aheterogeneous group of hematopoietic malignancies that occurs worldwide. The use of a chemical approach combined with genetic manipulation, great progresshas been achieved over the past few decades on the biological, molecular andcytogenetic aspects of leukemia, and in its diagnosis and therapy.In particular, discoveries of the clinical effectiveness of all-trans retinoic acid and arsenictrioxide in the treatment of acute promyelocytic leukemia and the kinase inhibitors Imatinib and Dasatinib in the treatment of chronic myelogenous leukemia not only make target therapy of leukemia a reality but but also push mechanisms of leukemo-genesis and leukemic cell activities forward .This rev iew will outline advances inchemical biology that help our understanding of the molecular mechanisms of cell differentiation and apoptosis induction and target therapy of leukemia.