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1950年前后一些作者开始注意到,某些急性白血病患者在其白血病显露之前,可先有一段不能确诊为白血病的血液学异常时期。1953年Block等首先集中报告了12例这样的患者,并称之为“白血病前期性急性白血病”。二十多年来,白血病前期(简称PL)这一现象已经得到广泛的承认。虽然用现有的诊断技术还不能事先确诊PL,但近十几年来不少作者从多方面进行的深入研究,已经为提高PL诊断水平、阐明PL本质等积累了有益的资料。
Some authors began to notice before and after 1950 that some patients with acute leukemia may have a period of hematologic abnormalities that can not be diagnosed with leukemia before their leukemia is revealed. In 1953 Block et al first focused on the report of 12 such patients, and called “leukemia pre-acute leukemia.” For more than two decades, the phenomenon of pre-leukemia (referred to as PL) has been widely recognized. Although the existing diagnostic techniques can not be used to diagnose PL in advance, many authors conducted in-depth studies in more than ten years and accumulated useful information for improving the diagnosis of PL and clarifying the essence of PL.