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本文研究了叶绿酸（ＣＨＬ）对７，１２—二甲基苯蒽（ＤＭＢＡ）诱发大鼠乳腺癌的影响。４３天龄雌性Ｓｐｒａｇｕｅ—Ｄａｗｌｅｙ大鼠随机分为３组，每组２５只。给ＤＭＢＡ前Ⅰ组给自来水，Ⅱ、Ⅲ组在饮水中加ＣＨＬ１．５ｍｍｏｌ，ｌｗｋ后每只大鼠一次灌胃给ＤＭＢＡ１０ｍｇ．给ＤＭＢＡ后Ⅰ、Ⅱ组给自来水，Ⅲ组饮水中继续加ＣＨＬ，持续２４ｗｋ。结果３组大鼠乳癌发生率分别为５０．０％、３３．３％和２３．８％．给ＣＨＬ的两组与对照组比较有下降趋势，但差异无显著性，说明ＣＨＬ的抗癌作用还有待进一步证实。实验中未发现ＣＨＬ有促癌作用。
In this paper, the effect of chlorophyllin (CHL) on breast cancer induced by 7,12-dimethylbenzyl anthracene (DMBA) in rats was studied. 43-day-old female Sprague-Dawley rats were randomly divided into 3 groups of 25 rats each. To DMBA before the group I to tap water, Ⅱ, Ⅲ group in the drinking water plus CHL1.5mmol, lwk after each rat to stomach DMBA10mg. After DMBA to give Ⅰ, Ⅱ group to tap water, Ⅲ group continue to add drinking water CHL, sustained 24wk. Results The incidence of breast cancer in the three groups was 50.0%, 33.3% and 23.8% respectively. There was a declining trend between CHL group and control group, but the difference was not significant, indicating that the anticancer effect of CHL remains to be confirmed. CHL was not found in the experiment have cancer-promoting effect.