【摘 要】
：
Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia (AML). Moreover, methotrexate (MTX) was chosen as model drug and encapsulate within folic acid
【机 构】
：
Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science
【出 处】
：
武汉理工大学学报（材料科学版）（英文版）
论文部分内容阅读
Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia (AML). Moreover, methotrexate (MTX) was chosen as model drug and encapsulate within folic acid modified carboxymethyl chitosan (FA-CMCS) nanoparticles through self-assembling. The chemical structure, morphology, release and targeting of nanoparticles were characterized by routine detection. It is demonstrated that the mean diameter is about 150 nm, the release rate increases with the decreasing of pH, the binding rate of CD33 antibody and FA-CMCS nanoparticles is about 5:2, and nanoparticles can effectively bind onto HL60 cells in vitro. The experimental results indicate that the FA-CMCS nanoparticles conjugated with antibody may be used as a potential pH-sensitive drug delivery system with leukemic targeting properties.
其他文献
A new research method was proposed(A/S method) to study the components and properties of reclained asphalt mixture (RAP). The RAP was divided into two main parts, one was marked with A that included all the reclaimed old asphalt materials(including some p
Aiming at overcoming the low plasticity of magnesium alloy at room temperature,we researched viscous warm pressure bulging(VWPB) of AZ31B magnesium alloy based on the excellent thermal stability of viscous medium under the warm forming condition.The poten
We investigated the simulation of the cracking and ablation behavior of ferro-siliceous and siliceous nuclear sacriifcial concretes. To this end, four type of sacriifcial concretes were fabricated,i e, the ferro-siliceous (F) and siliceous (S) plain concr
The feasibility of using different generations recycled coarse aggregate (RCA) on structural concrete was fully evaluated by studying the performance of the recycled coarse aggregates and their corresponding concretes, the different generations of RCA wer
Carbon quantum dots (CQDs) exhibit tremendous advantages for plant growth study due to its strong fluorescence and good biocompatibility. The fluorescent CQDs were synthesized by the one-step microwave method with the raw materials of citric acid (CA) and
As a kind of special material in geotechnical engineering, the mudded weak interlayer plays a crucial part in slope stability. In this paper, we presented a method to determine the threshold value of section micrographs of the mudded weak interlayer in sl
Durability design of recycled high performance concrete (RHPC) is fundamental for improving the use rate and level of concrete waste as coarse recycled aggregate (CRA). We discussed a frost-durability-based mix proportion design method for RHPC using 100