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探讨溶栓治疗对急性心肌梗死 (AMI)患者空腹胰岛素及胰岛素抵抗的影响。检测 2 0例溶栓治疗和 2 2例未溶栓治疗的非糖尿病 AMI患者的空腹血糖 ,空腹胰岛素及胰岛素敏感性指数 ,并与 2 0例正常人作比较 ,AMI患者 4周后复查。结果 :AMI两组在急性期存在高胰岛素血症和胰岛素抵抗 ,4周后复查血胰岛素水平 ,胰岛素敏感性指数较急性期有明显下降 (P<0 .0 1) ,AMI溶栓治疗组的空腹胰岛素和胰岛素敏感性指数较未溶栓治疗组显著下降 (P<0 .0 5 )。结论 :AMI存在高胰岛素血症及胰岛素抵抗 ,以急性期最明显 ,早期溶栓治疗能促进空腹胰岛素及胰岛素敏感性指数的下降
To investigate the effect of thrombolytic therapy on fasting insulin and insulin resistance in patients with acute myocardial infarction (AMI). The fasting blood glucose, fasting insulin and insulin sensitivity index of 20 patients with thrombolytic therapy and 22 without AMI were measured and compared with 20 normal subjects. AMI patients were reviewed after 4 weeks. Results: There were hyperinsulinemia and insulin resistance in acute AMI group. After 4 weeks, the blood insulin level was rechecked. The insulin sensitivity index was significantly lower than that in acute phase (P <0.01). The AMI thrombolytic therapy group The fasting insulin and insulin sensitivity index decreased significantly compared with those without thrombolysis (P <0.05). Conclusion: AMI has hyperinsulinemia and insulin resistance. The most obvious acute phase, thrombolytic therapy can promote fasting insulin and insulin sensitivity index decreased