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目的 :研究健康人口服加替沙星片后药代动力学特征。方法∶10名健康受试者单剂口服加替沙星片 2 0 0mg ,反相高效液相色谱法 (HPLC)测其血清、尿药物浓度。结果∶受试者单剂口服加替沙星片 2 0 0mg后 ,人体耐受良好 ,体内过程符合二室开放模型。药物口服后迅速吸收 ,达峰时间短 ,tmax为 (1.0 8± 0 .38)h ,血cmax为 (1.0 8± 0 .18)mg/L ,AUC0 -∞ 为 (9.0 1±0 .15 )mg·h/L ,V/Fc值为 (133.0 3± 36 .39)L/ 5 5kg。消除半衰期平均为 (7.84± 1.83)h ,48h尿累积回收率为 (6 2 .3± 8.0 )%。结论∶加替沙星口服吸收良好 ,血峰浓度高于敏感菌MIC值 ,组织分布广 ,2 0 0mg每日 1～ 2次口服可用于治疗常见敏感细菌感染。
Objective: To study the pharmacokinetics of gatifloxacin tablets in healthy volunteers. Methods: Ten healthy volunteers were given 200 mg gatifloxacin tablets and their serum and urinary concentrations were determined by reversed-phase high-performance liquid chromatography (HPLC). Results: Subjects received a single dose of gatifloxacin 200 mg tablets, the body is well tolerated, and the in vivo process conforms to the two-compartment open model. The drug rapidly absorbed after oral administration, the peak time was short, tmax was (1.08 ± 0.38) h, blood cmax was (1.08 ± 0.18) mg / L and AUC0-∞ was (9.0 1 ± 0.15) mg · h / L, V / Fc value of (133.0 3 ± 36.39) L / 5 5kg. The average elimination half-life was (7.84 ± 1.83) h, and the cumulative urine 48h recovery rate was (62.3 ± 8.0)%. Conclusion: Gatifloxacin is well absorbed orally, and its peak blood concentration is higher than that of susceptible strains. The tissue distribution is wide. It can be used orally once or twice daily to treat common sensitive bacterial infections.