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目的评价降钙素原(PCT)对新生儿败血症早期诊断的临床价值。方法选择入院日龄为2～26d的新生儿。据新生儿败血症诊断标准进行分组:非败血症组、单纯败血症组、败血症合并严重并发症组。按预先设定时间段对研究对象抽血分别进行PCT、超敏C反应蛋白(hsCRP)、血培养及血常规检测,并对资料进行统计分析。结果共入选38例,非败血症18例,单纯败血症15例,败血症合并严重并发症组5例。PCT作为新生儿败血症的早期诊断指标,其灵敏度和特异度优于hsCRP,且与败血症的严重程度相关性更强。结论血清PCT作为实验室检测指标,有助于新生儿败血症的早期诊断。
Objective To evaluate the clinical value of procalcitonin (PCT) in the early diagnosis of neonatal sepsis. Methods The neonates were selected on admission from 2 to 26 days old. According to neonatal sepsis diagnostic criteria for grouping: non-sepsis group, simple sepsis group, sepsis with serious complications group. According to the pre-set time period, the subjects were drawn blood to carry on the PCT, hsCRP, blood culture and blood routine examination, and the data were statistically analyzed. Results A total of 38 patients were enrolled. Among them, 18 were non-sepsis, 15 were simple sepsis, and 5 were sepsis with severe complications. PCT as an early indicator of neonatal sepsis is more sensitive and specific than hsCRP and is more relevant to the severity of sepsis. Conclusion Serum PCT as a laboratory test indicators, contribute to the early diagnosis of neonatal sepsis.