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目的探讨阿魏酸钠(SF)对冠心病患者血脂和血液流变学的影响。方法对70例确诊为冠心病(CHD)患者进行常规疗法,其中30例在此基础上加SF治疗,分别观察治疗前后血浆脂蛋白、血液流变学变化。结果阿魏酸钠显著降低血浆粘度、红细胞压积和血浆纤维蛋白原浓度,降低低密度脂蛋白浓度,升高高密度脂蛋白的浓度(P均<0.05)。结论 SF对血脂、血液流变学指标有不同程度的改善,对冠心病起到治疗和预防作用。
Objective To investigate the effect of sodium ferulate (SF) on blood lipid and hemorheology in patients with coronary heart disease. Methods Seventy patients diagnosed with coronary heart disease (CHD) were treated by conventional therapy. Thirty of them were treated with SF on the basis of this treatment. The changes of plasma lipoprotein and hemorheology were observed before and after treatment. Results Sodium ferulate significantly decreased plasma viscosity, hematocrit and plasma fibrinogen concentration, decreased the concentration of low density lipoprotein and increased the concentration of high density lipoprotein (P <0.05). Conclusion SF can improve blood lipids and hemorheology to some extent and play a therapeutic and preventive role on coronary heart disease.