1972年,Helgason和Lindqvist首先报道了一组肾脏患者尿嗜酸粒细胞(E)的测定。在尿白细胞百分率中,E>6％(0.06)15例;1～6％(0.01～0.06)20例,<1％(0.01)109例,仅高于0.06的15例患者有特殊意义。其中13例作了肾活检,未发现肾脏有E。作者假设尿E来自肾脏以外的尿路其他部位。1978年,Galpin等在9例由二甲氧苯青霉素(Methicillin)引起的间质性肾炎患者中,发现尿白细胞中E占10～60％。从此,尿E常作为各种原因所致的急性间质性肾炎的诊断依据。1985 In 1972, Helgason and Lindqvist first reported the determination of urinary eosinophilia (E) in a group of kidney patients. There were 15 cases with E> 6% (0.06), 10 cases with 1-6% (0.01-0.06), and <1% (0.01) 109 cases with urinary leukocytes. Thirteen of them had a kidney biopsy, and none of the kidneys had E. The authors hypothesized that urine E came from other parts of the urinary tract outside the kidneys. In 1978, Galpin et al found that 10% to 60% of E in urinary leukocytes was found in 9 patients with interstitial nephritis caused by methicillin. Since then, urine E often used as a diagnosis of acute interstitial nephritis due to various reasons. 1985