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目的:探讨外源性胆碱酯酶(ChE)辅助治疗急性重度有机磷农药中毒(ASOPP)的临床疗效。方法:202例ASOPP患者随机分为两组,治疗组:常规治疗基础上使用红细胞悬液治疗;对照组:常规治疗。治疗后对ChE活性及疗效进行对照比较。结果:治疗组中间综合征(IMS)发生率明显低于对照组;治疗组中毒症状、体征消失时间及住院平均天数均短于对照组(P<0.05)。结论:抢救ASOPP时补充外源性ChE,在缓解中毒症状、体征,缩短住院天数,防止和缓解IMS等方面都有明显改善,是ASOPP的有效救治途径。
Objective: To investigate the clinical efficacy of exogenous cholinesterase (ChE) in adjuvant treatment of acute severe organophosphorus pesticide poisoning (ASOPP). Methods: 202 patients with ASOPP were randomly divided into two groups: treatment group: conventional therapy based on the use of erythrocyte suspension treatment; control group: conventional treatment. ChE activity after treatment and efficacy comparison. Results: The incidence of intermediate syndrome (IMS) in the treatment group was significantly lower than that in the control group. The symptoms of poisoning, the disappearance of signs and the mean days of hospitalization in the treatment group were shorter than those in the control group (P <0.05). CONCLUSIONS: Exogenous ChE supplemented with ASOPP is an effective way to treat ASOPP when it is used to relieve symptoms and signs of poisoning, shorten the length of hospital stay, prevent and alleviate IMS, and so on.