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目的:探讨尿微量白蛋白(Alb)在新生儿窒息肾损伤中的价值。方法:取该院2004年8月～2005年10月收治的窒息后的新生儿47例,设为研究组,在入院后24～36h内采集尿液,以免疫透射比浊法检测尿微量蛋白。取同期无窒息及严重感染性疾病的住院患儿39例,设为对照组,进行上述检测;所有病例在获得尿液同时取股静脉血分别查Cr、BUN对照。结果:发现研究组尿Alb异常发生率明显高于对照组,差异有显著性(P<0.05),且重度窒息组>轻度窒息组>对照组,差异有显著性(P<0.05)。结论:尿Alb是检测肾小球功能的特异性指标之一,并与窒息程度密切相关,对窒息引起的早期肾损害诊断具有实用价值。
Objective: To investigate the value of urinary albumin (Alb) in neonatal asphyxia kidney injury. Methods: Forty-seven newborns with asphyxia admitted to our hospital from August 2004 to October 2005 were enrolled in the study group. Urine was collected within 24-36 hours after admission and urine microalbumin was detected by immunoturbidimetry . Take the same period without asphyxia and serious infectious diseases inpatients 39 cases, as the control group, the above test; all cases of urine while taking the femoral vein were checked Cr, BUN control. Results: The incidence of urinary Alb abnormalities in study group was significantly higher than that in control group (P <0.05), and severe asphyxia group> mild asphyxia group> control group (P <0.05). Conclusion: Urinary Alb is one of the specific indexes for detecting glomerular function and is closely related to the degree of asphyxia. It has practical value in the diagnosis of early renal damage caused by asphyxia.