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AIM:To measure circulating angiotensins at different stages of human cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes. METHODS:Patients were allocated into 4 groups:mild-to-moderate liver disease (MLD), advanced liverdisease (ALD), patients undergoing liver transplantation,and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) Ⅱ , Ang Ⅱ , and Ang-(1-7) levels using radioimmunoassays.During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components. RESULTS:PRA and angiotensins were elevated in ALD when compared to MLD and controls ( P < 0.05).In contrast, Ang Ⅱ was significantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation,Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the 0.02), whereas the peripheral circulating Ang Ⅱ /Ang Ⅱ ratio was elevated in comparison to splanchnic levels Ang Ⅱ ratios positively correlated with cardiac output ( r = 0.66) and negatively correlated with systemic vascular resistance ( r = -0.70).CONCLUSION:Our findings suggest that the relationship between Ang-(1-7) and Ang Ⅱ may play a role in the hemodynamic changes of human cirrhosis.