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目的观察辛伐他汀(降血脂药)对未合并冠心病的高胆固醇血症患者动脉僵硬度的影响。方法 51例高胆固醇血症患者应用辛伐他汀20 mg.d-1治疗12周,分别在0,12周测定患者的代谢指标、肱踝脉搏波传导速度(baPWV)。结果辛伐他汀治疗后,患者血浆总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均明显降低((P<0.01,P<0.05);与治疗前相比,双侧baPWV水平均显著降低(双侧均P<0.01)。结论辛伐他汀可改善无明确冠心病的高胆固醇血症患者动脉血管硬化程度。
Objective To observe the effect of simvastatin (hypolipidemic agents) on arterial stiffness in patients with hypercholesterolemia without coronary heart disease. Methods 51 patients with hypercholesterolemia were treated with simvastatin 20 mg.d-1 for 12 weeks. Metabolic parameters, brachial-ankle pulse wave velocity (baPWV) were measured at 0 and 12 weeks respectively. Results After treatment with simvastatin, the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were significantly decreased (P <0.01, P <0.05) (Both P <0.01) .Conclusion Simvastatin can improve the degree of arterial sclerosis in patients with hypercholesterolemia without definite coronary heart disease.