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在等降压剂量下吡那地尔(PIN,2mg·kg-1·d-1,ig)和赖诺普利(LIS,12mg·kg-1·d-1,ig)可使4月龄自发性高血压大鼠(SHR)的血压下降6.0~8.0kPa,并接近同种属正常血压大鼠的血压水平。PIN治疗30d后对SHR左室肥厚无明显作用,既不加重,也不减轻;对心脏舒张功能无明显影响,但有增强收缩功能的趋势。LIS治疗30d后,SHR心脏重量与体重之比有下降趋势,其心脏显著小于未治疗对照组,LIS可减轻左室肥厚。而LIS对心脏舒缩功能均无明显影响。PIN和LIS均降低主动脉射血量而不影响冠脉血流量。结果表明,PIN既不加重也不逆转左室肥厚,LIS可减轻左室肥厚,二者对心脏功能重构影响不明显
Pinacidil (PIN, 2 mg · kg-1 · d-1, ig) and lisinopril (LIS, 12 mg · kg-1 · d-1, ig) Spontaneous hypertensive rats (SHR) blood pressure decreased 6.0 ~ 8.0kPa, and close to the same kind of normal blood pressure in rats. PIN treatment of SHD after left ventricular hypertrophy had no significant effect, neither exacerbated nor alleviated; no significant effect on diastolic function, but there is a tendency to enhance systolic function. After 30 days of LIS treatment, the ratio of heart weight to body weight of SHR had a decreasing trend, and its heart was significantly smaller than that of untreated control group. LIS could reduce left ventricular hypertrophy. However, LIS had no significant effect on cardiac systolic and diastolic function. Both PIN and LIS decreased aortic ejection without affecting coronary flow. The results showed that PIN neither aggravate nor reverse left ventricular hypertrophy, LIS can reduce left ventricular hypertrophy, the two have no significant effect on cardiac remodeling