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[目的]观察大承气汤对急性胰腺炎的治疗效果,并通过观察其对过氧化物歧化酶(SOD)的影响,探讨其作用机理。[方法]将60例急性胰腺炎中医辨证属于腑实热结证患者随机分为2组,在常规西医治疗基础上,设立大承气汤组为治疗组,未使用大承气汤组为对照组。系统观察患者腹痛腹胀缓解时间、恶心呕吐缓解时间、胃肠道功能恢复时间,并且测定患者入院前及入院后第3、7、14天血清SOD的表达情况。[结果]治疗组能更有效地改善患者症状、体征,阻止SOD水平的下降。[结论]大承气汤的运用,能明显改善急性胰腺炎患者肠麻痹症状,缩短病程,缩短住院时间,减轻患者痛苦,并且能够通过提高血清SOD水平,提高机体清除氧自由基的能力,改善微循环障碍,减少组织损伤。
[Objective] To observe the therapeutic effect of Dachengqi Decoction on acute pancreatitis and to explore its mechanism by observing its effect on superoxide dismutase (SOD). [Methods] Sixty patients with TCM syndromes of acute pancreatitis were randomly divided into two groups. On the basis of routine Western medical treatment, Dachengqi Decoction group was set as the treatment group, while Dachengqi Decoction group was not used as the control group group. The patients’ abdominal pain and abdominal distension time, nausea and vomiting relief time and gastrointestinal function recovery time were systematically observed. The serum SOD expression before and 3, 7 and 14 days after admission was measured. [Results] The treatment group could improve the symptoms and signs of patients more effectively and prevent the decrease of SOD level. [Conclusion] The application of Dachengqi Decoction can obviously improve the symptoms of intestinal paralysis, shorten the course of disease, shorten the length of hospital stay and relieve the patients’ pain in patients with acute pancreatitis, and can improve the ability of scavenging oxygen free radicals by increasing serum SOD level Microcirculation, reduce tissue damage.