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目的观察小剂量阿糖胞苷、阿克拉霉素和粒细胞集落刺激因子联合(CAG方案)联合全反式维甲酸、亚砷酸治疗骨髓增生异常综合征难治性贫血伴原始细胞过多-Ⅱ(MDS-RAEB-Ⅱ)的临床疗效及不良反应。方法应用CAG+亚砷酸+维甲酸治疗MDS-RAEB-Ⅱ15例,15例患者中6例2疗程后达CR(40.0%),6例达PR(40.0%),总有效率为80.0%。15例患者均有不同程度的骨髓抑制,其余不良反应较轻。结论 CAG方案联合全反式维甲酸、亚砷酸治疗MDS-RAEB-Ⅱ,疗效较为满意。
Objective To observe the combination of low dose of cytarabine, aclacinomycin and granulocyte colony - stimulating factor (CAG) combined with all - trans retinoic acid and arsenious acid in the treatment of patients with myelodysplastic syndrome refractory anemia with excess of primitive cells - Ⅱ (MDS-RAEB-Ⅱ) clinical efficacy and adverse reactions. Methods Fifteen patients with MDS-RAEB-Ⅱ were treated with CAG + arsenite and retinoic acid. Six of 15 patients achieved CR (40.0%) after 2 courses of treatment and 6 patients achieved PR (40.0%). The total effective rate was 80.0%. All 15 patients had different degrees of myelosuppression, and the remaining adverse reactions were mild. Conclusion CAG regimen combined with all-trans retinoic acid, arsenite treatment of MDS-RAEB-Ⅱ, the effect is satisfied.