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目的:应用Meta分析方法研究基质金属蛋白酶MMP-1-1607 bp 1G/2G多态性和口腔癌易感性的关系。方法:检索各大数据库中符合纳入MMP-1-1607 bp 1G/2G启动子基因多态性与口腔癌易感性关系的病例对照研究,在各种不同遗传模型中进行对比,基因多态性与易感性的关系用比值比(OR)及95%可信区间(CI)表示,应用Rev Man 5.3软件对数据进行分析。结果:共纳入5篇研究,基于随机效应模型的Meta分析发现,1G/2G VS.2G/2G遗传模型OR=0.80,95%CI为0.53-1.20;1G VS.2G遗传模型OR=0.77,95%CI为0.54-1.11;2G/2G VS.1G/2G+1G/1G遗传模型OR=1.34,95%CI为0.87-2.06;1G/1G VS.1G/2G+2G/2G遗传模型OR=0.69,95%CI为0.36-1.36.结论:目前的文献尚不能证明MMP-1-1607 bp 1G/2G多态性和口腔癌易感性相关。
AIM: To investigate the relationship between MMP-1 -1607 bp 1G / 2G polymorphism and susceptibility to oral cancer using Meta-analysis. METHODS: A case-control study of the relationship between the gene polymorphism of 1-g / 2G promoter and the susceptibility to oral cancer in the major databases was performed and compared in various genetic models. The genetic polymorphism Susceptibility to the relationship between the odds ratio (OR) and 95% confidence interval (CI) that the use of Rev Man 5.3 software to analyze the data. Results: A total of 5 studies were included. Based on the meta-analysis of the random effects model, the OR of the 1G / 2G VS.2G / 2G genetic model was 0.80 and the 95% CI was 0.53-1.20. The OR of the 1G VS.2G genetic model was 0.77,95 The% CI was 0.54-1.11. The OR of the 2G / 2G VS.1G / 2G + 1G / 1G genetic model was 1.34 and the 95% CI was 0.87-2.06. The OR of the 1G / 1G VS.1G / 2G + 2G / 2G genetic model was 0.69 , 95% CI 0.36-1.36 .Conclusion: The current literature does not yet prove MMP-1-1607 bp 1G / 2G polymorphism associated with oral cancer susceptibility.