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目的评价辛伐他汀治疗对冠状动脉粥样斑块的影响。方法对73例经64层螺旋CT及回顾性心电门控技术检测出的冠脉粥样斑块患者,给予辛伐他汀40mg/d口服,18个月后复查斑块情况。同时随访患者的血脂水平。结果73例患者接受辛伐他汀调脂治疗后总胆固醇(TC)降低15.4%,LDL-C下降25.3%,TG下降14.2%,HDL-C增加8.5%。有202支冠状动脉存在224个粥样斑块,治疗后各种斑块大小有不同程度的缩小,其中脂质斑块(74个)缩小幅度25.4%(P<0.05);纤维斑块(58个)缩小幅度14.3%(P<0.05);混合斑块(47个)缩小幅度12.7%(P<0.05);而钙化斑块(45个)缩小幅度不明显(3.8%,P>0.05)。结论本试验证实长期服用辛伐他汀能够有效降低血脂水平,逆转或稳定冠脉粥样斑块,从而降低急性冠状动脉事件。
Objective To evaluate the effect of simvastatin on coronary atherosclerotic plaques. Methods A total of 73 patients with coronary atherosclerotic plaques detected by 64-slice spiral CT and retrospective ECG gating were given simvastatin 40 mg / d orally, and the plaques were reviewed 18 months later. At the same time, patients with blood lipid levels. Results The total cholesterol (TC) decreased by 15.4%, the LDL-C decreased by 25.3%, the TG decreased by 14.2% and the HDL-C increased by 8.5% in 73 patients receiving statin treatment. There were 224 atherosclerotic plaques in 202 coronary arteries. After treatment, the size of plaque decreased to some extent, of which, the reduction of lipid plaque (74) was 25.4% (P <0.05) (P <0.05). The number of mixed plaques (47) was reduced by 12.7% (P <0.05), while the calcified plaques (45) were not significantly reduced by 3.8% (P> 0.05). Conclusion This study demonstrates that long-term use of simvastatin can reduce blood lipid levels, reverse or stabilize coronary plaque, and thus reduce acute coronary events.