Gastrointestinal cancers rank the leading position in common malignancies in China.How to combat the delay in diagnosis,and enhance the multi-modalities treatment strategy for these life-threatening diseases are still the difficulties to be solved in this developing country.This mini-review is to analyze the status and regional distribution of clinical trials registered in intational and domestic websites,summarize the thoughts of study design,their clinical or translational research focus,thus to explore the state-of-the-art and trends of development in Chinese GI cancer researches.The numbers of registered clinical trials in common GI malignancies are increasing rapidly within the past decade,and the percentages distributed in different tumor types are in accordance with their incidence.Besides the trialsof investigated new drug (IND) for authority approval,more and more trials are focused on a specific clinical question,such as the preoperative nutritional support in malnutritional cancer patients.The trends of biomarker or biological-behavior oriented-design are progressively apparent.The concepts of whole-process management and precision medicine are gradually reflected in the trial designs.Meanwhile,the roles of Chinese investigators in intational collaborations are becoming more dominant from participant to team leaders.