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由于环子孢子(CS)蛋白具多态性,人们不得不考虑带有变异序列的疟原虫可能在宿主体内逃避疫苗免疫接种的作用,同时也必然会影响疟疾亚单位疫苗的效能。CS蛋白基因的顺序已在现场若干个恶性疟原虫(P.f.)及间日疟原虫(P.v.)的分离物中得到测定。研究表明P.v.的重复区及非重复区均有
Because of the polymorphism of the circumsporozoite (sp) protein, one has to consider that malaria parasites with variant sequences may evade vaccine immunization in the host, while also affecting the efficacy of the malaria subunit vaccine. The sequence of the CS protein gene has been determined on the spot in several isolates of P. falciparum and P. vivax. Studies have shown that both P.v. repeated and non-repetitive areas